{"id":4482,"date":"2018-11-07T13:03:59","date_gmt":"2018-11-07T11:03:59","guid":{"rendered":"https:\/\/adssc.org\/en\/?p=4482"},"modified":"2023-07-03T10:40:14","modified_gmt":"2023-07-03T08:40:14","slug":"rivka-ofir-ph-decology","status":"publish","type":"post","link":"https:\/\/www.adssc.org\/en\/rivka-ofir-ph-decology\/","title":{"rendered":"Ofir Rivka Ph.D

Signal transduction in health
and disease states<\/h4>"},"content":{"rendered":"\t\t
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Rivka Ofir Ph.D<\/h1>

\"\"<\/p>

Research Area:<\/strong>
Signal transduction in health and disease states<\/h3>

\"\" rivka@adssc.org<\/a>
\"\" 972-8-6581554
\"\"\u00a0972-8-6582068
\"\"\u00a0Google Scholar<\/a>
\"\"\u00a0ResearchGate<\/a>
Arava rift valley plant collection avpc<\/a><\/strong><\/p>

Current research:\u00a0<\/strong><\/div>
\u00a0<\/div>
  • Desert plants as source for new leads for drugs; Screening library of desert plants extracts against models for human diseases in c.elegans, zebrafish and cell lines.
    We have a library of ~250 desert plants collected in the Arava between the Red Sea and the Dead Sea. We extract the plant material in various solvents and screen the library of these extracts against\u00a0in vitro<\/em>\u00a0models of cancer diseases (tumors cell lines and cancer stem cells),\u00a0in vivo<\/em>\u00a0 models of neurodegenerative diseases (ALS disease in zebrafish and Alzheimer`s disease in c. elegans). The research will involve identifying \u00a0plant extracts with beneficial activities, to identify the active material, to unveil the model of action and cultivate the plants in stress conditions to mimic desert conditions.<\/li><\/ul>
    • Desert plants as source for safe fungicides and herbicides; Screening library of desert plants extracts against models for plant fungi and for inhibition of wild weeds.
      We have a library of ~250 desert plants collected in the Arava between the Red Sea and the Dead Sea. We extract the plant material in various solvents and screen the library of these extracts against various fungi isolated in the farms in the Arava.\u00a0 This library serve also for screening against germination and growth of wheat (Monocotyledon) and bean (Dicotyledon). \u00a0The research will involve identifying plant extracts with beneficial activities, to identify the active material, to unveil the model of action and cultivate the plants in stress conditions to mimic desert conditions.<\/li><\/ul>
      • Bioprospecting – medicinal metabolites\/transcript signatures for growth in desert stress conditions.
        According to our recent studies, the composition of the metabolites in desert plants depend on growth conditions (stress for irrigation, temperature, etc). The research will involve comparing the transcriptome and metabolome of desert plants with medicinal activities like\u00a0Achillea fragnitisoma<\/em>,\u00a0Pulicaria incisa<\/em>,\u00a0Boswellia sacra, Commiphora gileadensis<\/em>.<\/li><\/ul><\/div><\/div><\/div>
        \u00a0Publications:\u00a0<\/strong><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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