ד”ר רון סער דובר

• חקר אינטראקציות בין תאי מערכת החיסון לתאים סרטניים
• פיתוח שיטות לסריקת חומרים ברקמה Ex-vivo

פרסומים נבחרים:

• Frenkel N*, Saar Dover R*, E Titon, Y Shai, V Rom-Kedar (2021) Bistable bacterial growth dynamics in the presence of antimicrobial agents. Antibiotics 10, 87. (*equal contribution)
• Aran D, Saar Dover R, Lundy KE, Leipold MD, Xuhuai J, McDevitt SL, Davis MM, Butte AJ (2019) EpiSort: Enumeration of cell types using targeted bisulfite sequencing. bioRxiv, 677211.
• Bitler A, Saar Dover R, Shai Y (2018) Fractal properties of cell surface structures: A view from AFM. Seminars in cell & developmental biology 73, 64-70.
• Blazkova J, Gupta S, Liu Y, Gaudilliere B, Ganio EA, Bolen CR, Saar Dover R, et al. (2017) Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy. J Immunol. 15;198(6):2479-2488.
• Segev-Zarko L, Saar Dover R, Brumfeld V, Mangoni ML, and Shai Y (2017) Characterization of Anti-Biofilm Peptide Activity: A Biophysical Approach. Biophysical J. 112, 3, 23A.
• Saar Dover R, Bitler A, Shimoni E, Trieu-Cuot P, Shai Y (2015) Multiparametric AFM Reveals Turgor-Responsive Net-like Peptidoglycan Architecture in Live streptococci. Nature Communications 6:7193.
• Segev-Zarko L, Saar Dover R, Brumfeld V, Mangoni ML, and Shai Y (2015) Mechanisms of Biofilm Inhibition and Degradation by Antimicrobial Peptides. Biochem J 468, 259-270.
• Saar Dover R, and Shai Y (2013) CAMP-Membrane Interactions Using Fluorescence Spectroscopy. Bio-protocol 3, e846.
• Saar Dover R, Ashkenazi A and Shai Y (2013) Peptide Interaction with and Insertion into Membranes. Methods in Molecular Biology.
• Saar-Dover R, Bitler A, Nezer R, Shmuel-Galia L, Firon A, Shimoni E, Trieu-Cuot P, Shai Y (2012) D-alanylation of Lipoteichoic Acids Confers Resistance to Cationic Peptides in Group B streptococcus by Increasing the Cell Wall Density. PLoS Pathogens 8: e1002891.
• Bitler A, Dover R*, Shai Y (2012) Fractal Properties of Macrophage Membrane Studied by AFM. Micron 43:1239-1245. (*equal contribution)
• Papasergi S, Brega S, Mistou MY, Firon A, Oxaran O, Dover R, et al. (2011) The GBS PI-2a Pilus Is Required for Virulence in Mice Neonates. PLoS ONE 6(4): e18747.

פטנטים:

מחבר ומחזיק ב-7 פטנטים שונים העוסקים בטכנולוגיות של ביולוגיה מרחבית ובהרכבת ספריות לריצוף גנטי (NGS library construction)

Figure1: Multiplex antibody staining of a human tonsil with B-cells (CD21) surrouded by T-cell (CD3), endothelial vascularr cells (CD31) and epithelial capsule cell (Pan-cytokeratin).

Figure2: A solid human non-small cell lung adenocarcinoma (NSCLC) tumor stained with antibodies targeting tumor cells (CEACAM1, CD66a), T- and NK-cells (CD7), collagen producing stroma cells (CollagenIV) and proliferation (Ki67).